Costetti Dott. Alessandro
Pubblicazioni su PubMed
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Heterogeneity in Clinical Practices for Post-Cardiotomy Extracorporeal Life Support: a Pilot Survey from the PELS-1 Multicenter Study.
Artif Organs2023 Jun;():. doi: 10.1111/aor.14601.
Mariani Silvia, Bari Gabor, Ravaux Justine M, van Bussel Bas C T, De Piero Maria Elena, Schaefer Ann-Kristin, Jawad Khalil, Pozzi Matteo, Loforte Antonio, Kalampokas Nikolaos, Jankuviene Agne, Flecher Erwan, Hou Xiaotong, Bunge Jeroen J H, Sriranjan Kogulan, Salazar Leonardo, Meyns Bart, Mazzeffi Michael A, Matteucci Sacha, Sponga Sandro, Ramanathan Kollengode, Costetti Alessandro, Formica Francesco, Sakiyalak Pranya, Fiore Antonio, Schmid Chistof, Raffa Giuseppe Maria, Castillo Roberto, Wang I-Wen, Jung Jae-Seung, Grus Tomas, Pellegrino Vin, Bianchi Giacomo, Pettinari Matteo, Barbone Alessandro, Garcia José P, Kowalewski Mariusz, Shekar Kiran, Whitman Glenn,
Abstract
BACKGROUND:
High-quality evidence for post-cardiotomy extracorporeal life support (PC-ECLS) management is lacking. This study investigated the real-world PC-ECLS clinical practices.
METHODS:
This cross-sectional, multi-institutional, international pilot survey explored center organization, anticoagulation management, left ventricular unloading, distal limb perfusion, PC-ECLS monitoring and transfusions practices. Twenty-nine questions were distributed among 34 hospitals participating in the Post-cardiotomy Extra-Corporeal Life Support Study.
RESULTS:
Of the 32 centers [16 low-volume (50%); 16 high-volume (50%)] that responded, 16 (50%) had dedicated ECLS specialists. Twenty-six centers (81.3%) reported using additional mechanical circulatory supports. Anticoagulation practices were highly heterogeneous: 24 hospitals (75%) reported using patient's bleeding status as a guide, without a specific threshold in 54.2% of cases. Transfusion targets ranged 7-10 g/dL. Most centers used cardiac venting on a case-by-case basis (78.1%) and regular distal limb perfusion (84.4%). Nineteen (54.9%) centers reported dedicated monitoring protocols including daily echocardiography (87.5%), Swan-Ganz catheterization (40.6%), cerebral near-infrared spectroscopy (53.1%) and multimodal assessment of limb ischemia. Inspection of the circuit (71.9%), oxygenator pressure drop (68.8%), plasma free hemoglobin (75%), d-dimer (59.4%), lactate dehydrogenase (56.3%) and fibrinogen (46.9%) are used to diagnose hemolysis and thrombosis.
CONCLUSIONS:
This study shows remarkable heterogeneity in clinical practices for PC-ECLS management. More standardized protocols and better implementation of available evidence are recommended.
This article is protected by copyright. All rights reserved.
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Switch from minimally invasive biventricular mechanical support to cardiopulmonary bypass during heart transplant.
Eur J Cardiothorac Surg2021 Jan;59(1):271-273. doi: 10.1093/ejcts/ezaa343.
Settepani Fabrizio, Marianeschi Stefano Maria, Costetti Alessandro, Russo Claudio Francesco
Abstract
An easily reproducible surgical technique to switch from percutaneous minimally invasive biventricular mechanical support to cardiopulmonary bypass during heart transplantation is illustrated. After cannulation of the distal ascending aorta with a standard arterial cannula, the ProtekDuo® cannula and the ProtekSolo® Transseptal cannula were partially retracted to reach the superior and inferior vena cava, respectively, and connected to the pump circuit for the venous drainage. With this cardiopulmonary bypass configuration, orthotopic heart transplantation was routinely performed and, at the end of the procedure, the 2 cannulas were uneventfully removed.
© The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
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HeartWare-HVAD for end-stage heart failure: a review of clinical experiences with ?50 patients.
Expert Rev Med Devices2017 Jun;14(6):423-437. doi: 10.1080/17434440.2017.1325318.
Botta Luca, De Chiara Benedetta, Macera Francesca, Cannata Aldo, Costetti Alessandro, Voltolini Alessandra, Moreo Antonella, Cipriani Manlio, Frigerio Maria, Russo Claudio Francesco
Abstract
Despite the improvements in medical and surgical treatments, the incidence of end-stage heart failure (ESHF) continues to increase. Different mechanical systems have been adopted to support failing left ventricles. Among continuous-flow devices, the HeartWare-HVAD was the first to use a centrifugal pump rather than an axial one. Areas covered: In this review article, we provide an overview of the HeartWare-HVAD as a ventricular assist device for ESHF, discussing indications, echocardiographic assessment, surgical techniques, outcomes, concerns and controversies. Scientific literature was reviewed with a MEDLINE search strategy combining 'HeartWare' or 'HVAD' with 'heart failure'. A total of 263 papers were found using the reported search. From these, 16 were identified to provide the best evidence on the subject reporting outcomes in ?50 patients. Expert commentary: HeartWare-HVAD is a minute device that provides full circulatory support in patients with ESHF. Its main indication remains bridge to heart transplantation (HTx). Median sternotomy is the preferred technique of implantation although less invasive procedures have been described. Early outcomes are satisfactory. Nevertheless, some fearing complications still occur during the mid- and long-term follow-up. Further technical developments and optimal medical management will guarantee better outcomes.
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Off-pump Kommerell's diverticulum resection and descending aorta replacement.
J Card Surg2016 Aug;31(8):544-5. doi: 10.1111/jocs.12794.
Nicolò Francesca, Costetti Alessandro, Carro Cristina, Marianeschi Stefano Maria
Abstract
We report the case of an unusual variation of a Kommerell's diverticulum in a left aortic arch with an aberrant left subclavian artery, associated with dilatation of the distal aortic arch, surgically treated without the use of extracorporeal circulation.
© 2016 Wiley Periodicals, Inc.
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